Institution: QIMR Berghofer Medical Research Institute
Lead Researcher: Associate Professor Michelle Hill
Funding Awarded: $236,172
Year/s: 2018-2020

Associate Professor Michelle Hill is investigating an early detection test for ovarian cancer by searching for proteins in the blood which could be identified as ‘biomarkers’ of the disease, and therefore translated into a clinical test. Her approach involves identifying proteins in the blood with sugars attached, called glycoproteins. Changes in these proteins have been implicated in cancer, including ovarian. Associate Professor Hill used a similar method in lab research to detect oesophageal cancer, with promising results. She is optimistic her ovarian cancer investigations will lead to findings that can be used as the basis for a blood test to detect the disease.
Knowledge Building: Associate Professor Hill’s project aims to identify specific blood proteins that could form the basis for an early detection test. The most promising of the proteins tested are now being further studied in an international collaboration.
The team developed and optimised an assay for validation of a list of promising candidate glycoprotein biomarkers. This assay will now be used to measure a new group of patient samples to generate a shortlist for further development.